The Delta Sleep Inducing Peptide is on our short list of most loved peptides!
I’ve used it for over a year to help me sleep deeper and feel more refreshed in a noticeably shorter amount of time.
•••
Recently I wondered, could it especially benefit people with ASD or seizures by normalizing high or erratic nighttime brain waves?
Research says yes and doctors report success!
When trying it with my daughter, I wondered why I waited so long! (more below)
Note: it is a nasal spray but it works equally well sublingually
Delta Sleep-Inducing Peptide (DSIP) is a neuropeptide known for its potential to modulate brain activity, particularly by increasing time spent in restorative, delta wave activity

It is not a direct sedative, but rather a brain wave modulator, helping people spend more time in slow-wave sleep (SWS).
How could it help with ASD and Seizures?
Both ASD and seizure activity can be associated with atypical EEG patterns, including increased high-frequency (beta/gamma) activity or epileptiform discharges.
DSIP can modulate brain excitability, enhance delta waves, and calm neurotransmitters.

My Daughters Experience taking DSIP:
DSIP helps her fall asleep and sleep through the night – without the need for other sleep supplements or medication.
Our Review of DSIP – both blog post and video covers these topics:

And you can find it here: https://diaryofrecovery.com/dsip

But before you visit, if you’re interested in information specific ASD and Seizures, it’s below.
The blog link will be posted again at the end 🙂
Autism Specific Info
• ASD is associated with increased beta/gamma activity (high-frequency waves) and reduced delta/theta activity during sleep.
This can contribute to sensory processing issues, hyperactivity, and sleep disturbances.
Slowing nighttime brain waves can normalize these patterns.
• DSIP promotes short-wave sleep SWS, which is critical for memory consolidation and brain recovery.
Poor sleep exacerbates behavioral and cognitive symptoms in ASD, enhancing delta sleep can improve overall functioning.
• DSIP’s stress-protective effects can reduce hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, which is often dysregulated in ASD and linked to anxiety and sensory overload.

Seizure / Epilepsy Info
• Studies of metaphit-induced audiogenic seizures (a model of reflex epilepsy) demonstrate that DSIP significantly reduced seizure incidence, duration, and severity.
These effects are linked to increased delta and theta wave power in EEGs and decreased epileptiform activity (polyspikes, spike-wave complexes).
• DSIP potentiates the anticonvulsant effects of valproate, a standard antiepileptic drug, suggesting a synergistic role in epilepsy management.
• DSIP is categorized as an endogenous anticonvulsant, proposing it stabilizes brain excitability through interactions with dopaminergic, adrenergic, and GABAergic systems.

DSIP Mechanisms of Action
• DSIP increases delta and theta EEG activity — associated with calm, restorative states, potentially counteracting the high-frequency, erratic brain waves seen in ASD and epilepsy.
• It acts via NMDA receptor modulation, reducing excitatory glutamate activity, which is implicated in both seizures and ASD-related hyperexcitability.
• DSIP enhances GABA synthesis, promoting inhibitory neurotransmission, which could stabilize neural networks in seizures and ASD.
• Its ability to cross the blood-brain barrier and lack of toxicity at high doses make it a promising candidate for therapeutic use.
In summary – DSIP can help with ASD and Seizures because it:
Normalizes Brain Wave Patterns
– Shifts brain activity toward calmer, more synchronized states, reducing neural hyperexcitability.
Reduces Seizure Activity
– Stabilizes neural networks through NMDA receptor antagonism and GABAergic enhancement
Improves Sleep Quality
– Promotion of delta sleep enhances restorative sleep, improving memory consolidation and reducing irritability or sensory overload.
Mitigates Stress and Excitotoxicity
– Works via the HPA axis to lower anxiety and improve neural resilience.
Modulates Neurotransmitter Systems
– Reduces glutamatergic excitation, addressing the excitatory-inhibitory imbalance in ASD and epilepsy, promoting neural stability.
Safety Profile
DSIP is non-toxic even at high doses and crosses the blood-brain barrier, making it a feasible candidate for use in ASD and epilepsy.
If you want to give it a try, the links to purchase are at our blog post
It contains more on the topics:
(Links will take you to specific section of the post)
- What is Delta Sleep?
- What is the Delta Sleep Inducing Peptide & How it works
- Our experience & Dosing (including sublingual)
- Purchasing & pricing (~$40-50) w/ discounts
- Reminder of importance of sleep!
- Nasal spray mixing Demo (reconstitution)
Here’s the post and video:
https://diaryofrecovery.com/dsip

See you there!
For personalized help with sleep or anything –
Please consider our digital mind AI Tool, it has been helping hundreds of families achieve results!
Check it out here:

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Hi, Can you recommend anything that helps the need and addiction to stimming? Thanks Marguerite
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Possibly Selank but treating yeast with KpV is the best option
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Yeah, sourcing was what was tricky for me. I’ve had good results from apex peptides, and I used code PEPTIDEFAQ for a discount. I also found peptidefaq.com helpful for checking legit info before buying
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Thanks! We get it from limitless with the code QUALITY but you probably see that in the post 🙂
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